DeBartoloBreathe™
An exceptional bioavailable and well-tolerated source of magnesium
DESCRIPTION
DeBartoloBreathe™
contains a patented form of magnesium from Albion Laboratories with
demonstrated exceptional bioavailability and tolerance. Each
Vcaps™ vegetarian capsule supplies 150 mg of elemental magnesium as a
glycinate-lysinate chelate.
OVERVIEW
Magnesium is a critical intracellular
element and is required as a cofactor in more than 300 enzymes. As such,
it plays a fundamental role in numerous cellular functions including
energy production, cellular synthesis and proliferation, skeletal and
cardiac muscle excitability, neurochemical transmission, signal
transduction, bone formation, insulin secretion, normal intracellular
calcium, sodium and potassium levels, and the synthesis of carbohydrates,
proteins, lipids and nucleic acids. Magnesium and ATPase facilitate normal
calcium reuptake following contraction, thus initiating relaxation in both
smooth and skeletal muscle. Normal nerve and muscle cell stimulation
requires magnesium to assist with the synthesis and regulation of
acetylcholine. Thus, inadequate levels of magnesium may lead to serious
biochemical and symptomatic
disturbances including cardiac arrhythmia, coronary and cerebral
vasospasms, hypertension, asthma, fatigue, muscle weakness, tremors, and
cramps. The central nervous system may also be affected, resulting in
psychiatric disorders that range from very subtle changes such as
restlessness and irritability to depression or psychosis.
Magnesium deficiency is common among the
general population as its dietary intake has decreased over the years
especially in the Western world. National surveys consistently show low
levels of dietary intake of magnesium among all age groups and sexes. Food
processing is a major cause of magnesium depletion. For example, as much
as 85% of the magnesium content of whole wheat is lost when refined to
white flour. Deficiencies may also be caused by excessive calcium intake,
moderate-to-excessive alcohol consumption, gastrointestinal disturbances
(diarrhea, steatorrhea), renal dysfunction, diabetic ketoacidosis, and the
use of some diuretics, estrogens, and corticosteroids.
Proper magnesium balance depends on
efficient intestinal absorption coupled with adequate dietary intake. Many
commercial magnesium preparations are characterized by limited solubility
and bioavailability and, as magnesium oxide and inorganic magnesium salts,
may act as an osmotic laxative, with resultant diarrhea.
Magnesium is absorbed from the small
intestine. Its fractional absorption is influenced by dietary amount,
solubility, and the presence of inhibiting or promoting nutritional
factors. Magnesium salts must first dissociate into a free ion before they
can be absorbed either through passive absorption or binding to amino acid
carriers present in the diet. The absorption of the free ion is limited by
its susceptibility to adverse nutrient interactions. Magnesium salts are
also prone to inducing adverse gastrointestinal side effects including
diarrhea in some individuals.
One
of the prevalent pathways for magnesium absorption is via its formation of
amino acid chelates which pass readily through the intestinal epithelium.
The uptake of the magnesium amino acid chelate used in DeBartoloBreathe™
is at least 1.8 times greater than magnesium carbonate, 2.6 times greater
than magnesium sulfate, and 4.1 times greater than magnesium oxide. This
is likely due to its low molecular weight and size which allows it to be
readily absorbed without dissocation and binding to a carrier. As a
natural absorptive form, Albion’s magnesium amino chelate is
exceptionally well tolerated and has a very low incidence of adverse side
effects.
Asthma
Magnesium acts as a muscle relaxant and is
reported to play a beneficial role in the prevention and treatment of
asthma through relaxation of bronchial smooth muscle. Magnesium exerts its
relaxant effect by at least two mechanisms. It blocks voltage-dependent
calcium channels thereby inhibiting calcium influx and subsequent smooth
muscle contraction. It (in association with ATPase) allows for relaxation
following contraction by facilitating calcium reuptake. Studies have shown
that low dietary intake of magnesium and low plasma and leukocyte levels
are associated with an increase in broncho-constriction.
Bone Formation
Magnesium is essential for organic bone
matrix formation, preservation, and remodeling. Magnesium deficiency
alters calcium metabolism, resulting in hypocalcemia, vitamin D
abnormalities and neuromuscular hyperexcitability and as such may be a
significant risk factor for bone loss and osteoporosis. The primary reason
for the hypocalcemia commonly observed in magnesium deficiency is impaired
PTH secretion. Magnesium deficiency results in decreased bone strength and
volume, poor bone development, and uncoupling of bone formation and
resorption. Animal and human studies demonstrate a positive association
between magnesium intake and bone mineral density.
Blood Pressure
Considerable epidemiological data exits
suggesting that magnesium may play an important role in regulating blood
pressure. These studies report an inverse association between dietary
magnesium intake and incidence of hypertension. Several intervention
studies have shown that supplemental magnesium had a beneficial effect on
lowering elevated both systolic and diastolic blood pressure whereas
others have shown little or no effect.
Cardiovascular
Magnesium depletion is associated with
several cardiac complications, including
arrhythmias, increased platelet aggregation, hyperlipidemia,
athereosclerosis, arterial wall degeneration and calcification, and smooth
muscle constricture. Diets
rich in magnesium are inversely related to incidence of stroke,
particularly among hypertensive men. Magnesium may also reduce the
morbidity and mortality of patients following myocardial infarction.
Diabetes
Magnesium is involved in glucose
metabolism and insulin secretion and action. Among diabetics, more than
30% are hypomagnesemic. Low levels are seen in both childhood and
adult-onset diabetes and have been linked to insulin resistance and
abnormal glucose tolerance in individuals. Oral supplementation improves
glucose tolerance and insulin resistance in non-insulin-dependent patients
with diabetes.
INDICATIONS
DeBartoloBreathe™
is intended as a nutritional adjunct for individuals who wish to increase
their daily magnesium intake.
FORMULA
SUGGESTED
USE
One
to two capsules daily with food or as directed by physician.
ADVERSE
REACTIONS
None
reported. Diarrhea is reported with excess intake of inorganic magnesium
salts.
CONTRAINDICATIONS
Individuals
with renal disease should consult with their physician before taking a
magnesium supplement.
DRUG
INTERACTIONS
None
reported.
DRUG-INDUCED
NUTRIENT DEPLETION
Magnesium
deficiencies may result from use of diuretics, estrogens, and
corticosteroids.
HOW
SUPPLIED
100
capsules per bottle with full-bottle shrink-wrap. Packaged 12 bottles per
case.
STORAGE
Store
in a cool, dry place (59ºF-85ºF) away from direct light. Keep out of
reach of children.
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